Revista de la Facultad de Medicina Humana
English Title
Identificación de genotipos de Virus del Papiloma Humano en papilomatosis laríngea juvenil. Experiencia de 3 años en un hospital de concentración en Puebla, México
Abstract
Background: Juvenile laryngeal papillomatosis (JLP) is a chronic benign disease from viral etiology, whose clinical course can be aggressive. In Mexico, the Human Papillomavirus (HPV) genotypes that cause this disease have been poorly studied. Objective: To identify the HPV genotypes in patients with JLP in a reference Hospital in Puebla, Mexico. Mehods: A retrospective descriptive study was performed in patients with JLP attended in a 3rd level care of the Instituto Mexicano del Seguro Social in Puebla, México, from 2018 to 2021. Medical records were revised. In all patients, HPV identification was performed by polymerase chain reaction for genomes 6, 11, 16 and 18 using specific oligonucleotides. Descriptive statistics were applied. Results: 9 patients were included, 56% women, mean age 9.5 ±5.7 years; 7 patients were HPV-11 positive and 2 HPV-6. The mean age at diagnosis was 2.35 ±1.77 years, with an average of 12 ±11.56 surgical procedures; 5 patients were tracheostomy carriers, 4 had genotype 11; 8 patients were born vaginally, but no patient had maternal genital condylomatous lesions. In the patient born by cesarean section, transmission due to sexual abuse was documented. Conclusions: The most frequent genotypes in patients with JLP in the south-central region of Mexico are HPV-6 and HPV-11, the latter one is predominating.
English Abstract
La papilomatosis laríngea juvenil (PLJ) es una enfermedad benigna crónica de etiología viral, con un curso clínico agresivo. En México se han estudiado pobremente los genotipos del Virus del Papiloma Humano (VPH) que causan la enfermedad. El objetivo de este estudio fue identificar los genotipos del VPH en los pacientes con PLJ. Se realizó un estudio descriptivo y retrospectivo, se revisaron expedientes de los pacientes con PLJ atendidos en un hospital de México, en el periodo 2018-2021. En todos los pacientes se identificó el VPH para los genomas 6, 11, 16 y 18. Se incluyeron 9 pacientes, 56% mujeres, edad media 9,5 ±5,7 años; 7 pacientes registraron positividad al VPH-11 y 2 al VPH-6. La edad media al diagnóstico fue 2,35 ±1,77 años, con promedio de procedimientos quirúrgicos de 12 ± 11,56. En conclusión, los genotipos más frecuentes en pacientes con PLJ fueron VPH-6 y VPH-11, predominando este último.
DOI
https://doi.org/10.25176/RFMH.v23i1.5088
Recommended Citation
García-Galicia, Arturo; Andrade-Bonilla, Clotilde Margarita; Vallejo-Ruiz, Verónica; Vallejo-Domínguez, Blanca Elena; Ramírez-Mendoza, Janeth; Montiel-Jarquín, Álvaro José; Bertado-Ramírez, Nancy Rosalía; and Loría-Castellanos, Jorge
(2023)
"Identification of Human Papillomavirus genotypes in juvenile laryngeal papillomatosis. Three-year experience in a concentration hospital in Puebla, Mexico,"
Revista de la Facultad de Medicina Humana: Vol. 23:
Iss.
1, Article 11.
DOI: https://doi.org/10.25176/RFMH.v23i1.5088
Available at:
https://inicib.urp.edu.pe/rfmh/vol23/iss1/11
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