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Revista de la Facultad de Medicina Humana

English Title

Implicancias clínicas de la biología molecular del cáncer de próstata: Artículo de revisión

Keywords

Prostatic Neoplasms, Genetic Heterogeneity, Germ-Line Mutation

English Keywords

Neoplasias de la Próstata, Heterogeneidad Genética, Mutación de Línea Germinal

Abstract

To understand the term genomic heterogeneity in prostate cancer, we must understand the clonal genomic evolution of cancer, as well as knowing that it is a dynamic and evolutionary phenomenon. Knowing the genome of prostate cancer not only allows us to have a vision over time of the genomic alterations that occur during its different stages, but also to learn about the mechanisms of metastasis. In addition, knowing the hereditary component of prostate cancer allows the evaluation of patients and to be able to identify if we are dealing with a family at risk.

English Abstract

El cáncer de próstata es, desde el punto de vista molecular, biológicamente heterogéneo debido a la diversidad de alteraciones moleculares inter e intratumorales, siendo además un proceso genómico dinámico y evolutivo. Con el desarrollo de nuevas técnicas moleculares, como el secuenciamiento génico, microarreglos, estudios epigenenómicos, entre otros, se ha podido caracterizar molecularmente al cáncer de próstata, encontrándose diferencias incluso entre los diferentes estadíos de la enfermedad.

DOI

https://doi.org/10.25176/RFMH.v22i3.5043

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